Animal models of Multiple Sclerosis

Curcumin ameliorates oxidative stress in animal models of multiple sclerosis

Background & Objectives: The role of oxidative stress in the pathogenesis of Multiple Sclerosis (MS) has been mentioned in previous studies. Curcumin is an active ingredient in Curcuma longa and has anti-inflammatory properties. The aim of this study was to investigate the effects of curcumin on reducing the oxidative stress in the animal model of MS. Materials & Methods: In this study, experim...

Multiple Sclerosis: Animal Models and Treatment Options

Multiple sclerosis is an inflammatory autoimmune-mediated disease of the Central Nervous System (CNS). Different treatment protocols, based on neurotropic viral infections and/or immunization with CNS proteins, have been implemented. Although there are encouraging outcomes, cure is still far from reach. Here, we discuss some of these treatment options.

Proteomic strategies in multiple sclerosis and its animal models.

The early and precise diagnosis, the prognosis, and the clinical management of multiple sclerosis, remain a considerable challenge. In recent years, the development of novel and powerful proteomic techniques prompted the use of these approaches for the search of unique biomarkers in the cerebrospinal fluid of multiple sclerosis patients. A few studies have also utilized proteomics to delineate ...

Experimental Models of Multiple Sclerosis Experimental Models of Multiple Sclerosis

MAKING AN EXPERIMENTAL ANIMAL MODEL FOR MULTIPLE SCLEROSIS

To understand the mechanism of Multiple Sclerosis (MS), an autoimmune demyelinating disease, the researchers developed an experimental animal model for MS, which is called EAE (Experimental Allergic Encephalomyelitis). There are several methods for inducing this animal model. In this research the active EAE, which is developed by injecting bovine myelin antigens into genetically susceptibl...